Mouradian's National Lacrosse League experience as a General Manager dates back to 1992 with the expansion Buffalo Bandits. With the Bandits from 1992 to 1997, he won the league's championship three times (including the inaugural season) and made the playoffs every season. Mouradian added to his championships with the Toronto Rock in both 1999 and 2000. Mouradian is the only General Manager in the NLL to win five championships.
In 2003, Mouradian was named the General Manager and Head Coach to the expansion San Jose Stealth. He served as Head Coach for the 2004 and 2005 NLL season. In 2004 he was named National Lacrosse League GM of the Year Award.
In February 2008, Mouradian was inducted into the National Lacrosse League Hall of Fame.
As a player, Mouradian played collegiate lacrosse at Ithaca College, and is a member of the school's Hall of Fame. He was also a member of the 1978 Team Canada, which upset Team USA in the World Lacrosse Championships.